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The metformin research suggests plausibility for similar effects with semaglutide , but the mechanisms differ enough that direct extrapolation remains uncertain

In the presence of GSH, GPX4 continuously reduce PLOOHs, and if GSH depletion or GPX4 inactivation, intracellular ferrous ions induce ferroptosis by breaking down PLOOHs to cause lipid peroxidation (Ursini and Maiorino, 2020)

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Iron overload and human disease The bodys total iron stores may be increased due to several conditions, which collectively are referred to as iron overload disorders